The paper deals with the problem of the occurrence of volatile organic compounds in the work environment, specifically in administrative public buildings in the context of the quality of the indoor environment (IAQ). The importance of indoor air quality has become an interest in research and development in the last 10 years, mainly due to the increasing quality of the airtight envelope of the building and the prevailing trend of forced ventilation. Indoor air quality is directly related to Sick Building Syndrome (SBS). The occurrence of VOC emissions within 10 selected office buildings in the South Bohemian Region in the Czech Republic is demonstrated in the practical case study. Detection of volatile organic compounds was performed using ultra-fast electronic zNose Model 4200 Analyzer based on gas chromatography with patented SAQ detector. The results of the case study demonstrate how important a quality element and the necessary implementation of the building and the design of the indoor working environment is.