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The current societal trend is to reduce energy consumption and emissions of substances harmful to human health and threatening the climate and biodiversity. Buildings account for 40% of total energy consumption in the EU, and the sector is growing steadily. Buildings also account for 36% of greenhouse gas emissions. It is therefore clear that the energy status of buildings plays a significant role in both the economy and people's lives. ETICS (External Thermal Insulation Composite System) of buildings is particularly beneficial in energy savings. However, the impact on human health and the environment is not investigated enough, both during construction and during the lifetime and demolition of the structure. Financial demands and thermal insulation properties are usually main criteria for the selection of the best insulation. However, the impact on the environment and public health should also be taken into account. The aim of the paper is to find the most suitable variants of thermal insulation using appropriate statistical methods considering all aspects. This means considering not only variables involving thermal, technical, operational, economic, but also health and environmental aspects. Products that are friendly to the health of the population and the environment also bring economic benefits, which are sometimes difficult to quantify.