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@article{55781, author = {Strunecká, Anna and Strunecký, Otakar}, article_location = {Switzerland}, article_number = {20}, doi = {http://dx.doi.org/10.3390/app10207100}, keywords = {Aluminofluoride complexes; Autism spectrum disorders; Enzymes; Fluoride toxicity; G proteinsI; Q deficits; Magnesium; Neurotoxicity; Phosphate}, language = {eng}, issn = {2076-3417}, journal = {Applied Sciences}, title = {Mechanisms of fluoride toxicity: From enzymes to underlying integrative networks}, url = {http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=C5ABlKURYcXNXgIKdtV&page=1&doc=1}, volume = {10}, year = {2020} }
TY - JOUR ID - 55781 AU - Strunecká, Anna - Strunecký, Otakar PY - 2020 TI - Mechanisms of fluoride toxicity: From enzymes to underlying integrative networks JF - Applied Sciences VL - 10 IS - 20 SP - 1-24 EP - 1-24 PB - MDPI SN - 20763417 KW - Aluminofluoride complexes KW - Autism spectrum disorders KW - Enzymes KW - Fluoride toxicity KW - G proteinsI KW - Q deficits KW - Magnesium KW - Neurotoxicity KW - Phosphate UR - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=C5ABlKURYcXNXgIKdtV&page=1&doc=1 L2 - http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=1&SID=C5ABlKURYcXNXgIKdtV&page=1&doc=1 N2 - Fluoride has been employed in laboratory investigations since the early 20th century. These studies opened the understanding of fluoride interventions to fundamental biological processes. Millions of people living in endemic fluorosis areas suffer from various pathological disturbances. The practice of community water fluoridation used prophylactically against dental caries increased concern of adverse fluoride effects. We assessed the publications on fluoride toxicity until June 2020. We present evidence that fluoride is an enzymatic poison, inducing oxidative stress, hormonal disruptions, and neurotoxicity. Fluoride in synergy with aluminum acts as a false signal in G protein cascades of hormonal and neuronal regulations in much lower concentrations than fluoride acting alone. Our review shows the impact of fluoride on human health. We suggest focusing the research on fluoride toxicity to the underlying integrative networks. Ignorance of the pluripotent toxic effects of fluoride might contribute to unexpected epidemics in the future. ER -
STRUNECKÁ, Anna and Otakar STRUNECKÝ. Mechanisms of fluoride toxicity: From enzymes to underlying integrative networks. \textit{Applied Sciences}. Switzerland: MDPI, vol.~10, No~20, p.~1-24. ISSN~2076-3417. doi:10.3390/app10207100. 2020.
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