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New technologies are rapidly changing the structure of our economy and social life. The Fourth Industrial Revolution does not bring fundamental changes only in the area of industrial production because its overlap is much wider. The Fourth Industrial Revolution brings a number of challenges but also opportunities to ensure the long-term competitiveness of the Czech Republic in a global international environment as we live in a material world of modern times that has an impact on the quality of life of an individual in a society of many generations. The key prerequisite for successful adaptation and implementation of the changes is the use of opportunities as a challenge including the elimination of potential risks with the emphasis of the preventive measures implemented in Industry 4.0 as a consensus of strategic direction and sustainable development of the Czech Republic's competitiveness at the governmental level under the auspices of the Prime Minister and Ministers of the relevant ministries, entities, educational and research organizations and non-governmental and non-profit organizations. It is necessary for Czech companies to accept new approaches and standards of the international market, to reduce dependence on German customers and to extend the strategy of economic growth to other economically advanced countries of the international market.