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The chapter “The conclusion” of the expert collective monograph “South Bohemian Region in Global Economy” analyses the main sectors of South Bohemian economy from 2004 until today. It focuses on the influence of globalization and its processes, on the labor market analysis, on the small and middle enterprises, on the analysis of the innovation activities of enterprises, on agricultural production, on the food industry, on tourism and on using regional foods. The monograph also presents a financial analysis of big exporters and an evaluation of the current state of direct foreign investments. The research of the management field includes the analysis of stakeholders of small and middle enterprises, the analysis of human resources management and of investments in the human capital, including the analysis of language education. On the basis of many questionnaire inquiries, statistical data analysis and other materials, the authors come to the conclusion that the unemployment rate in the South Bohemian region does not significantly differ from the countrywide rate. They also confirmed that South Bohemian enterprises are not different from innovators in the remaining regions and that their main problem still is the transformation of scientific and research expenses into innovation outputs it the form of new products and services. They further came to the conclusion that the state of the South Bohemian agriculture significantly improved since joining the European Union in 2004. While analyzing the direct foreign investments, the authors proved that the volume of the investments is over time relatively stable when compared to other regions of the Czech republicLast but not least, the authors learned that the enterprise management in the human resources field is not secured by appropriate expert quality. The authors confirmed the still very strong position of the German language in the language education field in the South Bohemian Region.