The chapter „Foreign direct investment: assessment of state, potential and support options“ of the expert collective monograph “The South Bohemian Region in Global Economy” showed that the activity of foreign investors in the South Bohemian region is generally lower than in the rest of the Czech Republic. The most significant causes were indentified in the field of infrastructure as well as in missing industrial traditions and in specific features of the region that support further development of tourism and other service sectors rather than the development of industry. Data regarding regional FDI movements and detailed information about the projects under the investment incentives scheme were evaluated using comparative criteria; to support the interpretation, practical examples and qualitative criteria and practical examples were also examined in brief. General assumptions and possibilities regarding the potential of future involvement of this region in the FDI flows are outlined in the conclusion.