All components of a huge machine tool need to work together perfectly to ensure not only a quality finished product, but operator safety. One of those many components is the material of support panels and moving parts in the machine construction. Mechanical structure of the machine, in most cases does not reach the technical level of regulatory techniques or electric drives and potential increase in dynamics, speed or accuracy of the machines remain unused. Used classic construction materials, steel or light alloy then zoom in to limit their physical capabilities. Designers have machine tools or robots are forced to solve the formidable task in the form of reducing the weight of the moving parts while maintaining or even increasing stiffness with respect to the thermal stability or damping. Laminates are for construction of production machines, robots and manipulators of crucial importance. One big advantage is the high rigidity while maintaining low specific weight. The presented paper is focused on the investigation of composite sandwich construction produced by prepreg technology, which is the suitable production choose for construction of machine tools parts. First of all, the production of sandwich structures with cork core, honeycomb core and foam cores are compared and described. In terms of the production process it is a method very friendly to the environment, since there are no leaks styrene vapours into the air. Since it is important from the perspective of a manufacturer of transport or machine industry manufactured from environmentally friendly materials, so naturally from materials that are from the perspective of safety of passengers (operators of machine tools or robots) at a high level, when any accident was lowest possible hazard due to fire (burn materials used) and terms of the strength of composite materials. This is one of the major scientific articles and to find the most ideal surveyed composite sandwich materials that would be the greatest possible extent fulfils the required properties. In the experimental part of the article are compared and investigated the mechanical characteristics of composite sandwich structures with regard to varying number of layers of predimpregnated skin materials due to the different types of core materials suitable for use in the machine industry. In addition, these characteristics are an important part of the article research because described the influence number of layers to values of the bending stiffness those composite structures. © (2014) Trans Tech Publications, Switzerland.